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Research
- Basic
Basic Biomedical Research
The focus of the basic biomedical research program is The Cellular and Molecular Biology of Aging, including mechanisms
of gene action in the regulation of cellular aging' protein degradation, mitochondrial dysfunction, osteoporosis, and
Alzheimer's pathogenesis. This effort is led by Dr. Sue Griffin, the 1999 UAMS Academic Scholar. The Donald W. Reynolds
Department of Geriatrics team of basic biomedical researchers includes:
- Dr. Sue Griffin
- Dr. Griffin focuses on the mechanisms involved in the
progression of Alzheimer's Disease. Recently, Dr. Griffin
has discovered a link between the presence of a certain
immuni-response-generated cytokine, Interleukin-1, and the
increased probability of onset of Alzheimer's Disease. This
is seen as a significant breakthrough in the early detection
and treatment of Alzheimer's, and it has drawn nationwide
acclaim for Dr. Griffin and the Donald W. Reynolds Department
of Geriatrics.
- Dr. Steven Barger
- The focus of Dr. Barger's work is the molecular signaling
in Alzheimer pathogenesis. He has been supported by a FIRS
award from the NIA and by a Research Investigator Award
from the Alzheimer's Disease and Related Disorders Association.
He was also the first Inglewood Scholar at the Donald W.
Reynolds Institue on Aging.
- Dr. Mark D. Crew
- Dr. Crew researches gene action in the regulation of immune
cell aging.
- Dr. Beata Lecka-Czernik
- Funded by a NIH starter grant, Dr. Lecka-Czernik conducts
research on the changes in bone marrow stem cells during
aging.
- Dr. David A. Lipschitz
- The Chair of the Department of Geriatrics, Dr. Lipschitz'
research into aging effects on membrane lipids and lymphocyte
and neutrophil signal transduction is supported by a regular
research grant from the National Institute on Aging and
by a VA Merit Review Award.
- Dr. Joan McEwen
- The American heart Association, the National Institute
on Aging, and a VA Merit Review grant support Dr. McEwen's
research into mitochondrial synthesis, assembly, and function.
- Dr. Charlotte Peterson
- Three NIH grants have helped Dr. Peterson form the foundation
of her successful research into the maintenance of muscle
mass during aging.
- Dr. Usha Ponnappan
- Dr. Ponnappan has conducted research on protein degradation
in immune senescence.
- Dr. Robert J. Shmookler
Reis - Dr. Reis researches the genetics of cellular
senescence.
- Dr. Jin G. Sheng
- Another researcher studying Alzheimer pathogenesis, Dr.
Sheng is making discoveries that may lead to new treatments
for Alzheimer patients.
- Dr. Kodetthoor Udupa
- Dr. Udupa's research focus is the study of macrophage,
erythropoiesis and aging.
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